Eliminating All Obstacles: Regulated Proteolysis in the Eukaryotic Cell Cycle
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چکیده
منابع مشابه
Eliminating All Obstacles: Regulated Proteolysis in the Eukaryotic Cell Cycle
from E2 to a specific substrate usually requires a ubiquiEukaryotic cell cycle research took a quantum leap fortin-ligase activity (E3). E3 activities are provided by diward approximately ten years ago when it was appreciverse and sometimes large and complex protein assemated that a conserved class of protein kinases propels blies. Substrate specificity is believed to be a major the cell throug...
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The ubiquitin-dependent proteolysis of mitotic cyclin B, which is catalyzed by the anaphase-promoting complex/cyclosome (APC/C) and ubiquitin-conjugating enzyme H10 (UbcH10), begins around the time of the metaphase-anaphase transition and continues through G1 phase of the next cell cycle. We have used cell-free systems from mammalian somatic cells collected at different cell cycle stages (G0, G...
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issue concerning the cell cycle, and E3 complexes provide the key to regulated proteolysis. Two E3 complexes Houston, Texas 77030 were discovered through studies of cell cycle regulation: the cyclosome/anaphase-promoting complex (APC) and the SCF complex. One hundred years from now when the dust of the pres-Classes of Ubiquitination Substrates ent has long settled and the wizened eye of history...
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Research in the past 15 years has shown that the mammalian cell cycle is controlled by the action of cyclin-dependent kinases (CDKs). A crucial substrate of the CDKs in G1-phase is the retinoblastoma tumor suppressor (pRB), which restrains proliferation largely by repressing the activity of the E2F transcription factors. More recent work has shown that the cell cycle is also a tale of two class...
متن کاملCell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1.
CDC6 is conserved during evolution and is essential and limiting for the initiation of eukaryotic DNA replication. Human CDC6 activity is regulated by periodic transcription and CDK-regulated subcellular localization. Here, we show that, in addition to being absent from nonproliferating cells, CDC6 is targeted for ubiquitin-mediated proteolysis by the anaphase promoting complex (APC)/cyclosome ...
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ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80396-7